Type 2 diabetes mellitus T2DM is a worldwide epidemic, which by all predictions will only increase. To help in combating the devastating array of phenotypes associated with T2DM a highly reproducible and human disease-similar mouse model is required for researchers. These methods to model human T2DM have their benefits and their detractions. As far as modeling the majority of T2DM cases, HFD establishes the proper etiological, pathological, and treatment options. A limitation of HFD is that it requires months of feeding to achieve the full spectrum of T2DM symptoms and no standard protocol has been established. This paper will attempt to rectify the last limitation and argue for a standard group of HFD protocols and standard analysis procedures. There are a number of open issues in the HFD mouse modeling of T2DM: i Will these mouse models be useful in preclinical investigations? Comparisons between papers, genetic manipulations, and therapies will be much easier and more informative if a specific diet, length of diet, and analysis protocols can be agreed upon. The presentation of such a large and highly important body of work is daunting.
After three days on the 16 th day of treatment, the animals were subjected to glycemic tests. Watanabe, M. Yogurt supplementation also significantly reduced the levels of oxidative stress markers in the plasma and liver of HF diet-fed rats. The food consumption in gram was lower in NFD 3. Akt and mTOR pathyway integrates several important signals that regulate cell growth and metabolism. Uskova, M. Reprints and Permissions. Efird et al.
High-fat diet and streptozotocin in the induction of type 2 diabetes mellitus: a new proposal. KUME 1. NAIR H. An oral glucose tolerance test OGTT was performed 2. After 39 days of treatment, blood and tissue samples were collected for analyses. The combination of high-fat diet with STZ i. It is considered a worldwide public health problem and contributes to various complications, such as vision loss, bacterial and viral infections, emotional trauma, chronic renal failure, and vascular complications, which may progress to a state of disability or death Sheetz , Kawahito et al. Diabetes mellitus is classified as type 1 DM1 or type 2 DM2. In addition to genetic predisposition, its occurrence is due to factors such as increased longevity of the population, malnutrition hypercaloric food with low nutritional value, physical inactivity, obesity, and aging Defronzo and Abdul-ghani DM2 is commonly characterized by hyperglycemia, insulin resistance, and insulin deficiency Maitra and Abbas