Obesity is reaching epidemic proportions and is a strong risk factor for a number of cardiovascular and metabolic disorders such as hypertension, type 2 diabetes, dyslipidemia, atherosclerosis, and also certain types of cancers. Despite the constant recommendations of health care organizations regarding the importance of weight control, this goal often fails. Genetic predisposition in combination with inactive lifestyles and high caloric intake leads to excessive weight gain. Even though there may be agreement about the concept that lifestyle changes affecting dietary habits and physical activity are essential to promote weight loss and weight control, the ideal amount and type of exercise and also the ideal diet are still under debate. For many years, nutritional intervention studies have been focused on reducing dietary fat with little positive results over the long-term. One of the most studied strategies in the recent years for weight loss is the ketogenic diet. Many studies have shown that this kind of nutritional approach has a solid physiological and biochemical basis and is able to induce effective weight loss along with improvement in several cardiovascular risk parameters.
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Reduction in appetite due to higher satiety effect of proteins [ 38, 40 ], effects on appetite control hormones [ 41 ] and to a possible direct appetite suppressant action of the ketone bodies [ 42 ];. Bhupathiraju S. Recent studies also suggest that ketogenic diets may, in fact, induce hepatic insulin resistance Cox P. Miller W. Effect of protein intake on bone mineralization during weight loss: A 6-month trial.